Biologic Approaches to Treat Substance-Use Disorders.
Ontology highlight
ABSTRACT:
SUBMITTER: Skolnick P
PROVIDER: S-EPMC4593975 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Biologic Approaches to Treat Substance-Use Disorders.
Trends in pharmacological sciences 20151001 10
In contrast to traditional pharmacodynamic approaches to treat substance-use disorders (SUDs), the use of biologics (vaccines, monoclonal antibodies, and genetically modified enzymes) is based on a pharmacokinetic principle: reduce the amount of (and, ideally, eliminate) abused drug entering the central nervous system (CNS). Preclinical studies indicate that biologics are effective in both facilitating abstinence and preventing relapse to abused substances ranging from nicotine to heroin. While ...[more]
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