Ontology highlight
ABSTRACT:
SUBMITTER: Angata T
PROVIDER: S-EPMC4593978 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Trends in pharmacological sciences 20151001 10
The sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of immunomodulatory receptors whose functions are regulated by their glycan ligands. Siglecs are attractive therapeutic targets because of their cell type-specific expression pattern, endocytic properties, high expression on certain lymphomas/leukemias, and ability to modulate receptor signaling. Siglec-targeting approaches with therapeutic potential encompass antibody- and glycan-based strategies. Several antibody-based ...[more]