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Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches.

ABSTRACT: The sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of immunomodulatory receptors whose functions are regulated by their glycan ligands. Siglecs are attractive therapeutic targets because of their cell type-specific expression pattern, endocytic properties, high expression on certain lymphomas/leukemias, and ability to modulate receptor signaling. Siglec-targeting approaches with therapeutic potential encompass antibody- and glycan-based strategies. Several antibody-based therapies are in clinical trials and continue to be developed for the treatment of lymphoma/leukemia and autoimmune disease, while the therapeutic potential of glycan-based strategies for cargo delivery and immunomodulation is a promising new approach. Here we review these strategies with special emphasis on emerging approaches and disease areas that may benefit from targeting the Siglec family.

SUBMITTER: Angata T

PROVIDER: S-EPMC4593978 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches.

Angata Takashi T Nycholat Corwin M CM Macauley Matthew S MS

Trends in pharmacological sciences 20151001 10

The sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of immunomodulatory receptors whose functions are regulated by their glycan ligands. Siglecs are attractive therapeutic targets because of their cell type-specific expression pattern, endocytic properties, high expression on certain lymphomas/leukemias, and ability to modulate receptor signaling. Siglec-targeting approaches with therapeutic potential encompass antibody- and glycan-based strategies. Several antibody-based ...[more]

PMID: 26435210

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