Unknown

Dataset Information

0

Molecular Magnetic Resonance Imaging of Tumor Response to Therapy.


ABSTRACT: Personalized cancer medicine requires measurement of therapeutic efficacy as early as possible, which is optimally achieved by three-dimensional imaging given the heterogeneity of cancer. Magnetic resonance imaging (MRI) can obtain images of both anatomy and cellular responses, if acquired with a molecular imaging contrast agent. The poor sensitivity of MRI has limited the development of activatable molecular MR contrast agents. To overcome this limitation of molecular MRI, a novel implementation of our caspase-3-sensitive nanoaggregation MRI (C-SNAM) contrast agent is reported. C-SNAM is triggered to self-assemble into nanoparticles in apoptotic tumor cells, and effectively amplifies molecular level changes through nanoaggregation, enhancing tissue retention and spin-lattice relaxivity. At one-tenth the current clinical dose of contrast agent, and following a single imaging session, C-SNAM MRI accurately measured the response of tumors to either metronomic chemotherapy or radiation therapy, where the degree of signal enhancement is prognostic of long-term therapeutic efficacy. Importantly, C-SNAM is inert to immune activation, permitting radiation therapy monitoring.

SUBMITTER: Shuhendler AJ 

PROVIDER: S-EPMC4594000 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications


Personalized cancer medicine requires measurement of therapeutic efficacy as early as possible, which is optimally achieved by three-dimensional imaging given the heterogeneity of cancer. Magnetic resonance imaging (MRI) can obtain images of both anatomy and cellular responses, if acquired with a molecular imaging contrast agent. The poor sensitivity of MRI has limited the development of activatable molecular MR contrast agents. To overcome this limitation of molecular MRI, a novel implementatio  ...[more]

Similar Datasets

| S-EPMC5098733 | biostudies-literature
| S-EPMC10742077 | biostudies-literature
2023-11-03 | GSE239379 | GEO
| S-EPMC6231209 | biostudies-literature
| S-EPMC9671538 | biostudies-literature
| S-EPMC7661967 | biostudies-literature
| S-EPMC9248401 | biostudies-literature
| S-EPMC10503830 | biostudies-literature
| S-EPMC8267164 | biostudies-literature
2021-08-18 | MSV000088000 | MassIVE