Ontology highlight
ABSTRACT:
SUBMITTER: Hermann-Kleiter N
PROVIDER: S-EPMC4594157 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Hermann-Kleiter Natascha N Klepsch Victoria V Wallner Stephanie S Siegmund Kerstin K Klepsch Sebastian S Tuzlak Selma S Villunger Andreas A Kaminski Sandra S Pfeifhofer-Obermair Christa C Gruber Thomas T Wolf Dominik D Baier Gottfried G
Cell reports 20150917 12
Nuclear receptor subfamily 2, group F, member 6 (NR2F6) is an orphan member of the nuclear receptor superfamily. Here, we show that genetic ablation of Nr2f6 significantly improves survival in the murine transgenic TRAMP prostate cancer model. Furthermore, Nr2f6(-/-) mice spontaneously reject implanted tumors and develop host-protective immunological memory against tumor rechallenge. This is paralleled by increased frequencies of both CD4(+) and CD8(+) T cells and higher expression levels of int ...[more]