Energy coupling mechanisms of MFS transporters.
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ABSTRACT:
SUBMITTER: Zhang XC
PROVIDER: S-EPMC4594656 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Energy coupling mechanisms of MFS transporters.
Zhang Xuejun C XC Zhao Yan Y Heng Jie J Jiang Daohua D
Protein science : a publication of the Protein Society 20150918 10
Major facilitator superfamily (MFS) is a large class of secondary active transporters widely expressed across all life kingdoms. Although a common 12-transmembrane helix-bundle architecture is found in most MFS crystal structures available, a common mechanism of energy coupling remains to be elucidated. Here, we discuss several models for energy-coupling in the transport process of the transporters, largely based on currently available structures and the results of their biochemical analyses. Sp ...[more]
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