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Comparative study of serum proteomes in Legg-Calve-Perthes disease.


ABSTRACT: Legg-Calve-Perthes Disease (LCPD) is an idiopathic osteonecrosis of the developing femoral head complicated by pain and disability of the hip joint. To date, the pathological mechanisms of LCPD are not well-known. This study screened the changes in serum protein expression in patients with LCPD.Age- and sex-matched serum samples from 10 control subjects and 10 patients with LCPD were compared using the isobaric tags for relative and absolute quantification (iTRAQ) technique. Gene ontology analyses, KEGG pathway and functional network analyses were performed. Proteins of interest with large differences in expression, S100-A8, alpha-1-acid glycoprotein 1, haptoglobin and apolipoprotein E, were compared by western blotting.The disease/control ratios showed 26 proteins were significantly differentially expressed (all p?

SUBMITTER: Liu R 

PROVIDER: S-EPMC4595068 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Comparative study of serum proteomes in Legg-Calve-Perthes disease.

Liu Ruiyu R   Fan Lihong L   Yin Longbin L   Wang Kunzheng K   Miao Wusheng W   Song Qichun Q   Dang Xiaoqian X   Gao Hang H   Bai Chuanyi C  

BMC musculoskeletal disorders 20151005


<h4>Background</h4>Legg-Calve-Perthes Disease (LCPD) is an idiopathic osteonecrosis of the developing femoral head complicated by pain and disability of the hip joint. To date, the pathological mechanisms of LCPD are not well-known. This study screened the changes in serum protein expression in patients with LCPD.<h4>Methods</h4>Age- and sex-matched serum samples from 10 control subjects and 10 patients with LCPD were compared using the isobaric tags for relative and absolute quantification (iTR  ...[more]

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