Ontology highlight
ABSTRACT:
SUBMITTER: Malik M
PROVIDER: S-EPMC4595327 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Molecular neurodegeneration 20151005
In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies. We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological f ...[more]