Ontology highlight
ABSTRACT:
SUBMITTER: Deng X
PROVIDER: S-EPMC4595766 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Deng Xiaolong X Zhou Huan H Zhang Guiping G Wang Wenchao W Mao Langyong L Zhou Xing X Yu Yao Y Lu Hong H
Scientific reports 20151007
RNA interference (RNAi) is a widespread gene-silencing mechanism and is required for heterochromatin assembly in a variety of organisms. The RNA-induced transcriptional silencing complex (RITS), composed of Ago1, Tas3 and Chp1, is a key component of RNAi machinery in fission yeast that connects short interference RNA (siRNA) and heterochromatin formation. However, the process by which RITS is assembled is not well understood. Here, we identified Sgf73, a subunit of the SAGA co-transcriptional co ...[more]