Oral clofarabine for relapsed/refractory non-Hodgkin lymphomas: results of a phase 1 study.
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SUBMITTER: Abramson JS
PROVIDER: S-EPMC4595907 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
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Oral clofarabine for relapsed/refractory non-Hodgkin lymphomas: results of a phase 1 study.
Abramson Jeremy S JS Takvorian Ronald W RW Fisher David C DC Feng Yang Y Jacobsen Eric D ED Brown Jennifer R JR Barnes Jeffrey A JA Neuberg Donna S DS Hochberg Ephraim P EP
Leukemia & lymphoma 20130130 9
We conducted a phase 1 trial evaluating the oral nucleoside analog clofarabine in patients with relapsed/refractory non-Hodgkin lymphoma. Patients were treated once daily on days 1 through 21 of a 28-day cycle for a maximum of six cycles. The study was conducted with a 3 + 3 design with 10 additional patients treated at the recommended phase 2 dose. Thirty patients were enrolled including indolent B-cell lymphomas (n = 21), mantle cell lymphoma (n = 6) and diffuse large B-cell lymphoma (n = 3). ...[more]
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