Ontology highlight
ABSTRACT:
SUBMITTER: Dang H
PROVIDER: S-EPMC4596261 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Dang Hope H Klokk Tove I TI Schaheen Basil B McLaughlin Brooke M BM Thomas Anthony J AJ Durns Tyler A TA Bitler Benjamin G BG Sandvig Kirsten K Fares Hanna H
Traffic (Copenhagen, Denmark) 20110727 10
Cells have to maintain stable plasma membrane protein and lipid compositions under normal conditions and to remodel their plasma membranes in response to stimuli. This maintenance and remodeling require that integral membrane proteins at the plasma membrane that become misfolded, because of the relatively harsher extracellular milieu or carbohydrate and amino acid sequence changes, are degraded. We had previously shown that Derlin proteins, required for quality control mechanisms in the endoplas ...[more]