Ontology highlight
ABSTRACT:
SUBMITTER: Limberis MP
PROVIDER: S-EPMC4596530 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Limberis Maria P MP Adam Virginie S VS Wong Gary G Gren Jason J Kobasa Darwyn D Ross Ted M TM Kobinger Gary P GP Tretiakova Anna A Wilson James M JM
Science translational medicine 20130501 187
The emergence of a new influenza pandemic remains a threat that could result in a substantial loss of life and economic disruption worldwide. Advances in human antibody isolation have led to the discovery of monoclonal antibodies (mAbs) that have broad neutralizing activity against various influenza strains, although their direct use for prophylaxis is impractical. To overcome this limitation, our approach is to deliver antibody via adeno-associated virus (AAV) vectors to the site of initial inf ...[more]