Inflammation Induces TDP-43 Mislocalization and Aggregation.
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ABSTRACT:
SUBMITTER: Correia AS
PROVIDER: S-EPMC4596857 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Inflammation Induces TDP-43 Mislocalization and Aggregation.
Correia Ana Sofia AS Patel Priyanka P Dutta Kallol K Julien Jean-Pierre JP
PloS one 20151007 10
TAR DNA-binding protein 43 (TDP-43) is a major component in aggregates of ubiquitinated proteins in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Here we report that lipopolysaccharide (LPS)-induced inflammation can promote TDP-43 mislocalization and aggregation. In culture, microglia and astrocytes exhibited TDP-43 mislocalization after exposure to LPS. Likewise, treatment of the motoneuron-like NSC-34 cells with TNF-alpha (TNF-α) increased the cytoplasmic le ...[more]
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