Ontology highlight
ABSTRACT:
SUBMITTER: Bing T
PROVIDER: S-EPMC4597145 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Bing Tao T Shangguan Dihua D Wang Yinsheng Y
Molecular & cellular proteomics : MCP 20150721 10
Cancer biomarker discovery constitutes a frontier in cancer research. In recent years, cell-binding aptamers have become useful molecular probes for biomarker discovery. However, there are few successful examples, and the critical barrier resides in the identification of the cell-surface protein targets for the aptamers, where only a limited number of aptamer targets have been identified so far. Herein, we developed a universal SILAC-based quantitative proteomic method for target discovery of ce ...[more]