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Efficacy and HIV drug resistance profile of second-line ART among patients having received long-term first-line regimens in rural China.


ABSTRACT: Antiretroviral therapy has significantly expanded and an increased proportion of patients have switched to second-line regimens in China. We describe the outcomes of second-line therapy among patients having received long-term first-line ART. A prospective follow-up study was conducted in rural areas in China. We compared the virological, immunological outcomes and genotypic drug resistance (DR) profiles before and after regimen switches. A total of 303 patients were enrolled, 283 (93.4%) were retained at 12 months. Of 90 participants with HIV-RNA ??1000?copies/ml before switch, the proportion of viral load (VL)???1000?copies/ml at 6 and 12 months was 49.4% and 43.9%, respectively. Of 213 patients with HIV-RNA

SUBMITTER: Wang J 

PROVIDER: S-EPMC4597210 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Efficacy and HIV drug resistance profile of second-line ART among patients having received long-term first-line regimens in rural China.

Wang Jing J   Wang Zhe Z   Liu Jia J   Yue Yanchao Y   Yang Shimei S   Huang Huimin H   He Cui C   Liao Lingjie L   Xing Hui H   Ruan Yuhua Y   Shao Yiming Y  

Scientific reports 20151008


Antiretroviral therapy has significantly expanded and an increased proportion of patients have switched to second-line regimens in China. We describe the outcomes of second-line therapy among patients having received long-term first-line ART. A prospective follow-up study was conducted in rural areas in China. We compared the virological, immunological outcomes and genotypic drug resistance (DR) profiles before and after regimen switches. A total of 303 patients were enrolled, 283 (93.4%) were r  ...[more]

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