Kinase Identification with Supervised Laplacian Regularized Least Squares.
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ABSTRACT:
SUBMITTER: Li A
PROVIDER: S-EPMC4598036 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Kinase Identification with Supervised Laplacian Regularized Least Squares.
Li Ao A Xu Xiaoyi X Zhang He H Wang Minghui M
PloS one 20151008 10
Phosphorylation is catalyzed by protein kinases and is irreplaceable in regulating biological processes. Identification of phosphorylation sites with their corresponding kinases contributes to the understanding of molecular mechanisms. Mass spectrometry analysis of phosphor-proteomes generates a large number of phosphorylated sites. However, experimental methods are costly and time-consuming, and most phosphorylation sites determined by experimental methods lack kinase information. Therefore, co ...[more]
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