Fitness Landscapes of Functional RNAs.
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ABSTRACT:
SUBMITTER: Kun A
PROVIDER: S-EPMC4598650 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Fitness Landscapes of Functional RNAs.
Life (Basel, Switzerland) 20150821 3
The notion of fitness landscapes, a map between genotype and fitness, was proposed more than 80 years ago. For most of this time data was only available for a few alleles, and thus we had only a restricted view of the whole fitness landscape. Recently, advances in genetics and molecular biology allow a more detailed view of them. Here we review experimental and theoretical studies of fitness landscapes of functional RNAs, especially aptamers and ribozymes. We find that RNA structures can be divi ...[more]
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