Ontology highlight
ABSTRACT:
SUBMITTER: Kiel MJ
PROVIDER: S-EPMC4598843 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Kiel Mark J MJ Sahasrabuddhe Anagh A AA Rolland Delphine C M DCM Velusamy Thirunavukkarasu T Chung Fuzon F Schaller Matthew M Bailey Nathanael G NG Betz Bryan L BL Miranda Roberto N RN Porcu Pierluigi P Byrd John C JC Medeiros L Jeffrey LJ Kunkel Steven L SL Bahler David W DW Lim Megan S MS Elenitoba-Johnson Kojo S J KSJ
Nature communications 20150929
Sézary syndrome (SS) is an aggressive leukaemia of mature T cells with poor prognosis and limited options for targeted therapies. The comprehensive genetic alterations underlying the pathogenesis of SS are unknown. Here we integrate whole-genome sequencing (n=6), whole-exome sequencing (n=66) and array comparative genomic hybridization-based copy-number analysis (n=80) of primary SS samples. We identify previously unknown recurrent loss-of-function aberrations targeting members of the chromatin ...[more]