Ontology highlight
ABSTRACT:
SUBMITTER: Simpson PD
PROVIDER: S-EPMC4598998 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Simpson Peter D PD Eipper Betty A BA Katz Maximiliano J MJ Gandara Lautaro L Wappner Pablo P Fischer Roman R Hodson Emma J EJ Ratcliffe Peter J PJ Masson Norma N
The Journal of biological chemistry 20150819 41
Interactions between biological pathways and molecular oxygen require robust mechanisms for detecting and responding to changes in cellular oxygen availability, to support oxygen homeostasis. Peptidylglycine α-amidating monooxygenase (PAM) catalyzes a two-step reaction resulting in the C-terminal amidation of peptides, a process important for their stability and biological activity. Here we show that in human, mouse, and insect cells, peptide amidation is exquisitely sensitive to hypoxia. Differ ...[more]