Ontology highlight
ABSTRACT:
SUBMITTER: Casadevall D
PROVIDER: S-EPMC4599265 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Casadevall David D Gimeno Javier J Clavé Sergi S Taus Álvaro Á Pijuan Lara L Arumí Miriam M Lorenzo Marta M Menéndez Silvia S Cañadas Israel I Albanell Joan J Serrano Sergio S Espinet Blanca B Salido Marta M Arriola Edurne E
Oncotarget 20150601 18
<h4>Objective</h4>We aimed to assess MET intratumoral heterogeneity and its potential impact on biomarker-based patient selection as well as potential surrogate biomarkers of MET activation.<h4>Methods</h4>Our study included 120 patients with non-squamous Non-small-cell Lung Cancer (nsNSCLC), of which 47 were incorporated in tissue microarrays (TMA). Four morphologically distinct tumor areas were selected to assess MET heterogeneity. MET positivity by immunohistochemistry (IHC) was defined as an ...[more]