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By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer.

ABSTRACT: Microrchidia (MORC) family CW-type zinc-finger 2 (MORC2) regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis. Here, we found that MORC2 down-regulated p21 by recruiting HDAC1 to the p21 promoter, in a p53-independent manner. MORC2-mediated down-regulation of p21 in turn promoted cell cycle progression in gastric cancer cells. Furthermore, MORC2 expression correlated negatively with p21 expression in gastric tumors in patients. We suggest that MORC2 may be a potential therapeutic target in cancer.

SUBMITTER: Zhang Q

PROVIDER: S-EPMC4599282 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer.

Zhang Qing Q Song Yanyan Y Chen Wei W Wang Xiaohui X Miao Zhifeng Z Cao Liu L Li Feng F Wang Guiling G

Oncotarget 20150601 18

Microrchidia (MORC) family CW-type zinc-finger 2 (MORC2) regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis. Here, we found that MORC2 down-regulated p21 by recruiting HDAC1 to the p21 promoter, in a p53-independent manner. MORC2-mediated down-regulation of p21 in turn promoted cell cycle progression in gastric cancer cells. Furthermore, MORC2 expression correlated negatively with p21 expression in gastric tumors in patients. We sugg ...[more]

PMID: 26098774

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