Ontology highlight
ABSTRACT:
SUBMITTER: Dubois S
PROVIDER: S-EPMC4599301 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Dubois Sydney S Mareschal Sylvain S Picquenot Jean-Michel JM Viailly Pierre-Julien PJ Bohers Elodie E Cornic Marie M Bertrand Philippe P Veresezan Elena Liana EL Ruminy Philippe P Maingonnat Catherine C Marchand Vinciane V Lanic Hélène H Penther Dominique D Bastard Christian C Tilly Hervé H Jardin Fabrice F
Oncotarget 20150601 18
Enhancer of Zeste Homolog 2 (EZH2) plays an essential epigenetic role in Diffuse Large B Cell Lymphoma (DLBCL) development. Recurrent somatic heterozygous gain-of-function mutations of EZH2 have been identified in DLBCL, most notably affecting tyrosine 641 (Y641), inducing hyper-trimethylation of H3K27 (H3K27me3). Novel EZH2 inhibitors are being tested in phase 1 and 2 clinical trials but no study has examined which patients would most benefit from this treatment. We evaluated the immunohistoche ...[more]