Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity.
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ABSTRACT:
SUBMITTER: Gancarz AM
PROVIDER: S-EPMC4599345 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity.
Gancarz Amy M AM Wang Zi-Jun ZJ Schroeder Gabrielle L GL Damez-Werno Diane D Braunscheidel Kevin M KM Mueller Lauren E LE Humby Monica S MS Caccamise Aaron A Martin Jennifer A JA Dietz Karen C KC Neve Rachael L RL Dietz David M DM
Nature neuroscience 20150601 7
Activin receptor signaling, including the transcription factor Smad3, was upregulated in the rat nucleus accumbens (NAc) shell following withdrawal from cocaine. Direct genetic and pharmacological manipulations of this pathway bidirectionally altered cocaine seeking while governing morphological plasticity in NAc neurons. Thus, Activin/Smad3 signaling is induced following withdrawal from cocaine, and such regulation may be a key molecular mechanism underlying behavioral and cellular plasticity i ...[more]
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