Ontology highlight
ABSTRACT:
SUBMITTER: Leung DW
PROVIDER: S-EPMC4599368 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Cell reports 20150409 3
During viral RNA synthesis, Ebola virus (EBOV) nucleoprotein (NP) alternates between an RNA-template-bound form and a template-free form to provide the viral polymerase access to the RNA template. In addition, newly synthesized NP must be prevented from indiscriminately binding to noncognate RNAs. Here, we investigate the molecular bases for these critical processes. We identify an intrinsically disordered peptide derived from EBOV VP35 (NPBP, residues 20-48) that binds NP with high affinity and ...[more]