AIMing towards improved antitumor efficacy.
Ontology highlight
ABSTRACT:
SUBMITTER: Weaver MJ
PROVIDER: S-EPMC4599781 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
AIMing towards improved antitumor efficacy.
Weaver Matthew J MJ Kearns Alison K AK Stump Sascha S Li Chun C Gajewski Mariusz P MP Rider Kevin C KC Backos Donald S DS Reigan Philip R PR Beall Howard D HD Natale Nicholas R NR
Bioorganic & medicinal chemistry letters 20150303 8
Using the structure-activity relationship emerging from previous Letter, and guided by pharmacokinetic properties, new AIMs have been prepared with both improved efficacy against human glioblastoma cells and cell permeability as determined by fluorescent confocal microscopy. We present our first unambiguous evidence for telomeric G4-forming oligonucleotide anisotropy by NMR resulting from direct interaction with AIMs, which is consistent with both our G4 melting studies by CD, and our working hy ...[more]
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