Ontology highlight
ABSTRACT:
SUBMITTER: Brobey RK
PROVIDER: S-EPMC4599800 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Brobey Reynolds K RK German Dwight D Sonsalla Patricia K PK Gurnani Prem P Pastor Johanne J Hsieh C-C CC Papaconstantinou John J Foster Philip P PP Kuro-o Makoto M Rosenblatt Kevin P KP
PloS one 20151009 10
Klotho transgenic mice exhibit resistance to oxidative stress as measured by their urinal levels of 8-hydroxy-2-deoxyguanosine, albeit this anti-oxidant defense mechanism has not been locally investigated in the brain. Here, we tested the hypothesis that the reactive oxygen species (ROS)-sensitive apoptosis signal-regulating kinase 1 (ASK1)/p38 MAPK pathway regulates stress levels in the brain of these mice and showed that: 1) the ratio of free ASK1 to thioredoxin (Trx)-bound ASK1 is relatively ...[more]