Ontology highlight
ABSTRACT:
SUBMITTER: Lee A
PROVIDER: S-EPMC4599894 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Lee Ara A Park Seung Pyo SP Park Chan Hee CH Kang Byung Hyun BH Park Seong Hoe SH Ha Sang-Jun SJ Jung Kyeong Cheon KC
PLoS pathogens 20151009 10
Memory-like CD8+ T cells expressing eomesodermin are a subset of innate T cells initially identified in a number of genetically modified mice, and also exist in wild mice and human. The acquisition of memory phenotype and function by these T cells is dependent on IL-4 produced by PLZF+ innate T cells; however, their physiologic function is still not known. Here we found that these IL-4-induced innate CD8+ T cells are critical for accelerating the control of chronic virus infection. In CIITA-tran ...[more]