Unknown

Dataset Information

0

IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection.


ABSTRACT: Memory-like CD8+ T cells expressing eomesodermin are a subset of innate T cells initially identified in a number of genetically modified mice, and also exist in wild mice and human. The acquisition of memory phenotype and function by these T cells is dependent on IL-4 produced by PLZF+ innate T cells; however, their physiologic function is still not known. Here we found that these IL-4-induced innate CD8+ T cells are critical for accelerating the control of chronic virus infection. In CIITA-transgenic mice, which have a substantial population of IL-4-induced innate CD8+ T cells, this population facilitated rapid control of viremia and induction of functional anti-viral T-cell responses during infection with chronic form of lymphocytic choriomeningitis virus. Characteristically, anti-viral innate CD8+ T cells accumulated sufficiently during early phase of infection. They produced a robust amount of IFN-? and TNF-? with enhanced expression of a degranulation marker. Furthermore, this finding was confirmed in wild-type mice. Taken together, the results from our study show that innate CD8+ T cells works as an early defense mechanism against chronic viral infection.

SUBMITTER: Lee A 

PROVIDER: S-EPMC4599894 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection.

Lee Ara A   Park Seung Pyo SP   Park Chan Hee CH   Kang Byung Hyun BH   Park Seong Hoe SH   Ha Sang-Jun SJ   Jung Kyeong Cheon KC  

PLoS pathogens 20151009 10


Memory-like CD8+ T cells expressing eomesodermin are a subset of innate T cells initially identified in a number of genetically modified mice, and also exist in wild mice and human. The acquisition of memory phenotype and function by these T cells is dependent on IL-4 produced by PLZF+ innate T cells; however, their physiologic function is still not known. Here we found that these IL-4-induced innate CD8+ T cells are critical for accelerating the control of chronic virus infection. In CIITA-tran  ...[more]

Similar Datasets

| S-EPMC6207712 | biostudies-literature
| S-EPMC3435180 | biostudies-literature
| S-EPMC6683984 | biostudies-literature
| S-EPMC7554897 | biostudies-literature
| S-EPMC3967589 | biostudies-other
| S-EPMC4744528 | biostudies-literature
| S-EPMC4859432 | biostudies-literature
2023-02-16 | GSE225462 | GEO
2022-07-22 | GSE208537 | GEO
| S-EPMC4440206 | biostudies-other