Ontology highlight
ABSTRACT:
SUBMITTER: Kokkola T
PROVIDER: S-EPMC4600234 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Kokkola Tarja T Suuronen Tiina T Pesonen Maija M Filippakopoulos Panagis P Salminen Antero A Jarho Elina M EM Lahtela-Kakkonen Maija M Lahtela-Kakkonen Maija M
Chembiochem : a European journal of chemical biology 20150813 14
Control of histone acetylation is a part of the epigenetic mechanism that regulates gene expression and chromatin architecture. The members of the bromodomain and extra terminal domain (BET) protein family are a group of epigenetic readers that recognize histone acetylation, whereas histone deacetyl- ases such as sirtuin 1 (SIRT1) function as epigenetic erasers. We observed that BET inhibition by the specific inhibitor JQ1 upregulated SIRT1 expression and activated SIRT1. Moreover, we observed t ...[more]