Ontology highlight
ABSTRACT:
SUBMITTER: Sabbineni H
PROVIDER: S-EPMC4600438 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Sabbineni Harika H Alwhaibi Abdulrahman A Goc Anna A Gao Fei F Pruitt Alanna A Somanath Payaningal R PR
European journal of pharmacology 20150703
Isoform specific expression, intracellular localization and function of Akt in bladder cancer are not known. In the current study, we identified Akt1, followed by Akt2 and Akt3 as the predominant Akt isoform in human T24 and UM-UC-3 metastatic bladder cancer cells. Whereas Akt1 is localized at the membrane, cytoplasm and nucleus, Akt2 is solely cytoplasmic and Akt3 is mostly localized in the nucleus in T24 cells. ShRNA-mediated Akt1 knockdown resulted in impaired T24 cell survival, proliferation ...[more]