Ontology highlight
ABSTRACT:
SUBMITTER: Henderson VC
PROVIDER: S-EPMC4600817 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
eLife 20151013
Poor study methodology leads to biased measurement of treatment effects in preclinical research. We used available sunitinib preclinical studies to evaluate relationships between study design and experimental tumor volume effect sizes. We identified published animal efficacy experiments where sunitinib monotherapy was tested for effects on tumor volume. Effect sizes were extracted alongside experimental design elements addressing threats to valid clinical inference. Reported use of practices to ...[more]