Ontology highlight
ABSTRACT:
SUBMITTER: Gray WT
PROVIDER: S-EPMC4601059 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20150831 10
Catechol diether compounds have nanomolar antiviral and enzymatic activity against HIV with reverse transcriptase (RT) variants containing K101P, a mutation that confers high-level resistance to FDA-approved non-nucleoside inhibitors efavirenz and rilpivirine. Kinetic data suggests that RT (K101P) variants are as catalytically fit as wild-type and thus can potentially increase in the viral population as more antiviral regimens include efavirenz or rilpivirine. Comparison of wild-type structures ...[more]