Lack of Neuronal IFN-?-IFNAR Causes Lewy Body- and Parkinson's Disease-like Dementia.
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ABSTRACT:
SUBMITTER: Ejlerskov P
PROVIDER: S-EPMC4601085 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson's Disease-like Dementia.
Ejlerskov Patrick P Hultberg Jeanette Göransdotter JG Wang JunYang J Carlsson Robert R Ambjørn Malene M Kuss Martin M Liu Yawei Y Porcu Giovanna G Kolkova Kateryna K Friis Rundsten Carsten C Ruscher Karsten K Pakkenberg Bente B Goldmann Tobias T Loreth Desiree D Prinz Marco M Rubinsztein David C DC Issazadeh-Navikas Shohreh S
Cell 20151001 2
Neurodegenerative diseases have been linked to inflammation, but whether altered immunomodulation plays a causative role in neurodegeneration is not clear. We show that lack of cytokine interferon-β (IFN-β) signaling causes spontaneous neurodegeneration in the absence of neurodegenerative disease-causing mutant proteins. Mice lacking Ifnb function exhibited motor and cognitive learning impairments with accompanying α-synuclein-containing Lewy bodies in the brain, as well as a reduction in dopami ...[more]
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