Ontology highlight
ABSTRACT:
SUBMITTER: Ramiro AR
PROVIDER: S-EPMC4601098 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Ramiro Almudena R AR Jankovic Mila M Callen Elsa E Difilippantonio Simone S Chen Hua-Tang HT McBride Kevin M KM Eisenreich Thomas R TR Chen Junjie J Dickins Ross A RA Lowe Scott W SW Nussenzweig Andre A Nussenzweig Michel C MC
Nature 20060108 7080
Chromosomal translocations involving the immunoglobulin switch region are a hallmark feature of B-cell malignancies. However, little is known about the molecular mechanism by which primary B cells acquire or guard against these lesions. Here we find that translocations between c-myc and the IgH locus (Igh) are induced in primary B cells within hours of expression of the catalytically active form of activation-induced cytidine deaminase (AID), an enzyme that deaminates cytosine to produce uracil ...[more]