Ontology highlight
ABSTRACT:
SUBMITTER: Stoekenbroek RM
PROVIDER: S-EPMC4601145 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Stoekenbroek Robert M RM Kastelein John J P JJ Huijgen Roeland R
BMC medicine 20151012
Barely a decade after the discovery of the gene encoding proprotein convertase subtilisin/kexin type 9 (PCSK9) and its recognition as a key player in cholesterol metabolism, PCSK9 inhibition is now considered an exciting approach in the reduction of residual risk of cardiovascular disease. The progress from PCSK9 discovery to the development of targeted treatment has been unprecedented in terms of scale and speed. The first suggestion of a link between PCSK9 and hypercholesterolemia was publishe ...[more]