Ontology highlight
ABSTRACT:
SUBMITTER: Yoshikawa FS
PROVIDER: S-EPMC4601166 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Yoshikawa Fábio Seiti Yamada FS Ferreira Lucas Gonçalves LG de Almeida Sandro Rogério SR
Virulence 20150507 5
Dermatophytosis are one of the most common fungal infections in the world. They compromise keratinized tissues and the main etiological agent is Trichophyton rubrum. Macrophages are key cells in innate immunity and prominent sources of IL-1β, a potent inflammatory cytokine whose main production pathway is by the activation of inflammasomes and caspase-1. However, the role of inflammasomes and IL-1 signaling against T.rubrum has not been reported. In this work, we observed that bone marrow-derive ...[more]