Ontology highlight
ABSTRACT:
SUBMITTER: Chang GH
PROVIDER: S-EPMC4601187 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Chang Garry H K GH Lay Angelina J AJ Ting Ka Ka KK Zhao Yang Y Coleman Paul R PR Powter Elizabeth E EE Formaz-Preston Ann A Jolly Christopher J CJ Bower Neil I NI Hogan Benjamin M BM Rinkwitz Silke S Becker Thomas S TS Vadas Mathew A MA Gamble Jennifer R JR
Small GTPases 20140101 3
The formation of the vascular network requires a tightly controlled balance of pro-angiogenic and stabilizing signals. Perturbation of this balance can result in dysregulated blood vessel morphogenesis and drive pathologies including cancer. Here, we have identified a novel gene, ARHGAP18, as an endogenous negative regulator of angiogenesis, limiting pro-angiogenic signaling and promoting vascular stability. Loss of ARHGAP18 promotes EC hypersprouting during zebrafish and murine retinal vessel d ...[more]