Ontology highlight
ABSTRACT:
SUBMITTER: Hambuchen MD
PROVIDER: S-EPMC4601636 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Hambuchen Michael D MD Carroll F Ivy FI Rüedi-Bettschen Daniela D Hendrickson Howard P HP Hennings Leah J LJ Blough Bruce E BE Brieaddy Lawrence E LE Pidaparthi Ramakrishna R RR Owens S Michael SM
Journal of medicinal chemistry 20150522 11
We hypothesized that an anti-METH mAb could be used in combination with a METH-conjugate vaccine (MCV) to safely improve the overall quality and magnitude of the anti-METH immune response. The benefits would include immediate onset of action (from the mAb), timely increases in the immune responses (from the combined therapy) and duration of antibody response that could last for months (from the MCV). A novel METH-like hapten (METH-SSOO9) was synthesized and then conjugated to immunocyanin monome ...[more]