Ontology highlight
ABSTRACT:
SUBMITTER: Fokkink WJ
PROVIDER: S-EPMC4601728 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Fokkink Willem Jan R WJ Falck David D Santbergen Tom C M TC Huizinga Ruth R Wuhrer Manfred M Jacobs Bart C BC
PloS one 20151012 10
Intravenous immunoglobulin (IVIg) products from different pharmaceutical companies vary in composition, in part because of the selected blood donors and production process. N-glycosylation of the Fc-portion of IgG varies between blood donors and may influence both the side-effects and therapeutic effectiveness of IVIg. At present, the variation in Fc N-glycosylation between IVIg products has not been defined. Utilizing mass spectrometry, we performed relative quantitation of the Fc N-glycosylati ...[more]