Ontology highlight
ABSTRACT:
SUBMITTER: Fiore VF
PROVIDER: S-EPMC4602038 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Fiore Vincent F VF Strane Patrick W PW Bryksin Anton V AV White Eric S ES Hagood James S JS Barker Thomas H TH
The Journal of cell biology 20151001 1
Progressive fibrosis is characterized by excessive deposition of extracellular matrix (ECM), resulting in gross alterations in tissue mechanics. Changes in tissue mechanics can further augment scar deposition through fibroblast mechanotransduction. In idiopathic pulmonary fibrosis, a fatal form of progressive lung fibrosis, previous work has shown that loss of Thy-1 (CD90) expression in fibroblasts correlates with regions of active fibrogenesis, thus representing a pathologically relevant fibrob ...[more]