Ontology highlight
ABSTRACT:
SUBMITTER: Hyenne V
PROVIDER: S-EPMC4602040 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Hyenne Vincent V Apaydin Ahmet A Rodriguez David D Spiegelhalter Coralie C Hoff-Yoessle Sarah S Diem Maxime M Tak Saurabh S Lefebvre Olivier O Schwab Yannick Y Goetz Jacky G JG Labouesse Michel M
The Journal of cell biology 20151001 1
Exosomes are secreted vesicles arising from the fusion of multivesicular bodies (MVBs) with the plasma membrane. Despite their importance in various processes, the molecular mechanisms controlling their formation and release remain unclear. Using nematodes and mammary tumor cells, we show that Ral GTPases are involved in exosome biogenesis. In Caenorhabditis elegans, RAL-1 localizes at the surface of secretory MVBs. A quantitative electron microscopy analysis of RAL-1-deficient animals revealed ...[more]