Ontology highlight
ABSTRACT:
SUBMITTER: Woods B
PROVIDER: S-EPMC4602047 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Woods Benjamin B Kuo Chun-Chen CC Wu Chi-Fang CF Zyla Trevin R TR Lew Daniel J DJ
The Journal of cell biology 20151001 1
Establishment of cell polarity in animal and fungal cells involves localization of the conserved Rho-family guanosine triphosphatase, Cdc42, to the cortical region destined to become the "front" of the cell. The high local concentration of active Cdc42 promotes cytoskeletal polarization through various effectors. Cdc42 accumulation at the front is thought to involve positive feedback, and studies in the budding yeast Saccharomyces cerevisiae have suggested distinct positive feedback mechanisms. ...[more]