Ontology highlight
ABSTRACT:
SUBMITTER: Ovchinnikov S
PROVIDER: S-EPMC4602095 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
eLife 20150903
The prediction of the structures of proteins without detectable sequence similarity to any protein of known structure remains an outstanding scientific challenge. Here we report significant progress in this area. We first describe de novo blind structure predictions of unprecendented accuracy we made for two proteins in large families in the recent CASP11 blind test of protein structure prediction methods by incorporating residue-residue co-evolution information in the Rosetta structure predicti ...[more]