Aberrant expression of COT is related to recurrence of papillary thyroid cancer.
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ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC4602754 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Aberrant expression of COT is related to recurrence of papillary thyroid cancer.
Lee Jandee J Jeong Seonhyang S Park Jae Hyun JH Lee Cho Rok CR Ku Cheol Ryong CR Kang Sang-Wook SW Jeong Jong Ju JJ Nam Kee-Hyun KH Shin Dong Yeob DY Lee Eun Jig EJ Chung Woong Youn WY Jo Young Suk YS
Medicine 20150201 6
Aberrant expression of Cancer Osaka Thyroid Oncogene mitogen-activated protein kinase kinase kinase 8 (COT) (MAP3K8) is a driver of resistance to B-RAF inhibition. However, the de novo expression and clinical implications of COT in papillary thyroid cancer (PTC) have not been investigated.The aim of this study is to investigate the expression of A-, B-, C-RAF, and COT in PTC (n = 167) and analyze the clinical implications of aberrant expression of these genes.Quantitative polymerase chain reacti ...[more]
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