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Heart rate detrended fluctuation indexes as estimate of obstructive sleep apnea severity.


ABSTRACT: In the present study, we aimed at investigating a heart rate variability (HRV) biomarker that could be associated with the severity of the apnea-hypopnea index (AHI), which could be used for an early diagnosis of obstructive sleep apnea (OSA). This was a cross-sectional observational study on 47 patients (age 36?±?9.2 standard deviation) diagnosed with mild (23.4%), moderate (34%), or severe (42.6%) OSA. HRV was studied by linear measures of fast Fourier transform, nonlinear Poincaré analysis, and detrended fluctuation analysis (DFA)—DFA ?1 characterizes short-term fluctuations, DFA ?2 characterizes long-term fluctuations. Associations between polysomnography indexes (AHI, arousal index [AI], and oxygen desaturation index [ODI]) and HRV indexes were studied. Patients with different grades of AHI had similar sympathovagal balance levels as indicated by the frequency-domain and Poincaré HRV indexes. The DFA ?2 index was significantly positive correlated with AHI, AI, and ODI (Pearson r: 0.55, 0.59, and 0.59, respectively, with P?

SUBMITTER: da Silva EL 

PROVIDER: S-EPMC4602981 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Heart rate detrended fluctuation indexes as estimate of obstructive sleep apnea severity.

da Silva Eduardo Luiz Pereira ELP   Pereira Rafael R   Reis Luciano Neves LN   Pereira Valter Luis VL   Campos Luciana Aparecida LA   Wessel Niels N   Baltatu Ovidiu Constantin OC  

Medicine 20150101 4


In the present study, we aimed at investigating a heart rate variability (HRV) biomarker that could be associated with the severity of the apnea-hypopnea index (AHI), which could be used for an early diagnosis of obstructive sleep apnea (OSA). This was a cross-sectional observational study on 47 patients (age 36 ± 9.2 standard deviation) diagnosed with mild (23.4%), moderate (34%), or severe (42.6%) OSA. HRV was studied by linear measures of fast Fourier transform, nonlinear Poincaré analysis, a  ...[more]

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