Ontology highlight
ABSTRACT:
SUBMITTER: Fischer U
PROVIDER: S-EPMC4603357 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Fischer Ute U Forster Michael M Rinaldi Anna A Risch Thomas T Sungalee Stéphanie S Warnatz Hans-Jörg HJ Bornhauser Beat B Gombert Michael M Kratsch Christina C Stütz Adrian M AM Sultan Marc M Tchinda Joelle J Worth Catherine L CL Amstislavskiy Vyacheslav V Badarinarayan Nandini N Baruchel André A Bartram Thies T Basso Giuseppe G Canpolat Cengiz C Cario Gunnar G Cavé Hélène H Dakaj Dardane D Delorenzi Mauro M Dobay Maria Pamela MP Eckert Cornelia C Ellinghaus Eva E Eugster Sabrina S Frismantas Viktoras V Ginzel Sebastian S Haas Oskar A OA Heidenreich Olaf O Hemmrich-Stanisak Georg G Hezaveh Kebria K Höll Jessica I JI Hornhardt Sabine S Husemann Peter P Kachroo Priyadarshini P Kratz Christian P CP Te Kronnie Geertruy G Te Kronnie Geertruy G Marovca Blerim B Niggli Felix F McHardy Alice C AC Moorman Anthony V AV Panzer-Grümayer Renate R Petersen Britt S BS Raeder Benjamin B Ralser Meryem M Rosenstiel Philip P Schäfer Daniel D Schrappe Martin M Schreiber Stefan S Schütte Moritz M Stade Björn B Thiele Ralf R von der Weid Nicolas N Vora Ajay A Zaliova Marketa M Zhang Langhui L Zichner Thomas T Zimmermann Martin M Lehrach Hans H Borkhardt Arndt A Bourquin Jean-Pierre JP Franke Andre A Korbel Jan O JO Stanulla Martin M Yaspo Marie-Laure ML
Nature genetics 20150727 9
TCF3-HLF-positive acute lymphoblastic leukemia (ALL) is currently incurable. Using an integrated approach, we uncovered distinct mutation, gene expression and drug response profiles in TCF3-HLF-positive and treatment-responsive TCF3-PBX1-positive ALL. We identified recurrent intragenic deletions of PAX5 or VPREB1 in constellation with the fusion of TCF3 and HLF. Moreover somatic mutations in the non-translocated allele of TCF3 and a reduction of PAX5 gene dosage in TCF3-HLF ALL suggest cooperati ...[more]