Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.
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ABSTRACT:
SUBMITTER: Ciriello G
PROVIDER: S-EPMC4603750 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.
Ciriello Giovanni G Gatza Michael L ML Beck Andrew H AH Wilkerson Matthew D MD Rhie Suhn K SK Pastore Alessandro A Zhang Hailei H McLellan Michael M Yau Christina C Kandoth Cyriac C Bowlby Reanne R Shen Hui H Hayat Sikander S Fieldhouse Robert R Lester Susan C SC Tse Gary M K GM Factor Rachel E RE Collins Laura C LC Allison Kimberly H KH Chen Yunn-Yi YY Jensen Kristin K Johnson Nicole B NB Oesterreich Steffi S Mills Gordon B GB Cherniack Andrew D AD Robertson Gordon G Benz Christopher C Sander Chris C Laird Peter W PW Hoadley Katherine A KA King Tari A TA Perou Charles M CM
Cell 20151001 2
Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTEN, TBX3, and FOXA1 as ILC enriched features. PTEN loss associated with increased AKT phosphorylation, which was highest in ILC among all breast cancer subtypes. Spatially clustered ...[more]
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