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A review on hepatocyte nuclear factor-1beta and tumor.

ABSTRACT: Hepatocyte nuclear factor-1beta (HNF1?) was initially identified as a liver-specific transcription factor. It is a homeobox transcription factor that functions as a homodimer or heterodimer with HNF1?. HNF1? plays an important role in organogenesis during embryonic stage, especially of the liver, kidney, and pancreas. Mutations in the HNF1? gene cause maturity-onset diabetes of the young type 5 (MODY5), renal cysts, genital malformations, and pancreas atrophy. Recently, it has been shown that the expression of HNF1? is associated with cancer risk in several tumors, including hepatocellular carcinoma, pancreatic carcinoma, renal cancer, ovarian cancer, endometrial cancer, and prostate cancer. HNF1? also regulates the expression of genes associated with stem/progenitor cells, which indicates that HNF1? may play an important role in stem cell regulation. In this review, we discuss some of the current developments about HNF1? and tumor, the relationship between HNF1? and stem/progenitor cells, and the potential pathogenesis of HNF1? in various tumors.

SUBMITTER: Yu DD 

PROVIDER: S-EPMC4603907 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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A review on hepatocyte nuclear factor-1beta and tumor.

Yu Dan-Dan DD   Guo Shi-Wei SW   Jing Ying-Ying YY   Dong Yu-Long YL   Wei Li-Xin LX  

Cell & bioscience 20151013

Hepatocyte nuclear factor-1beta (HNF1β) was initially identified as a liver-specific transcription factor. It is a homeobox transcription factor that functions as a homodimer or heterodimer with HNF1α. HNF1β plays an important role in organogenesis during embryonic stage, especially of the liver, kidney, and pancreas. Mutations in the HNF1β gene cause maturity-onset diabetes of the young type 5 (MODY5), renal cysts, genital malformations, and pancreas atrophy. Recently, it has been shown that th  ...[more]

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