Ontology highlight
ABSTRACT:
SUBMITTER: Hammond GR
PROVIDER: S-EPMC4604148 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Hammond Gerald R V GR Takasuga Shunsuke S Sasaki Takehiko T Balla Tamas T
PloS one 20151013 10
Phosphatidylinositol (3,5)-bisphosphate (PtdIns(3,5)P2) is a quantitatively minor phospholipid in eukaryotic cells that plays a fundamental role in regulating endocytic membrane traffic. Despite its clear importance for cellular function and organism physiology, mechanistic details of its biology have so far not been fully elucidated. In part, this is due to a lack of experimental tools that specifically probe for PtdIns(3,5)P2 in cells to unambiguously identify its dynamics and site(s) of actio ...[more]