Ontology highlight
ABSTRACT:
SUBMITTER: Aung T
PROVIDER: S-EPMC4605818 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Nature genetics 20150223 4
Exfoliation syndrome (XFS) is the most common recognizable cause of open-angle glaucoma worldwide. To better understand the etiology of XFS, we conducted a genome-wide association study (GWAS) of 1,484 cases and 1,188 controls from Japan and followed up the most significant findings in a further 6,901 cases and 20,727 controls from 17 countries across 6 continents. We discovered a genome-wide significant association between a new locus (CACNA1A rs4926244) and increased susceptibility to XFS (odd ...[more]