The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers.
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ABSTRACT:
SUBMITTER: Han L
PROVIDER: S-EPMC4605878 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers.
Han Leng L Diao Lixia L Yu Shuangxing S Xu Xiaoyan X Li Jie J Zhang Rui R Yang Yang Y Werner Henrica M J HMJ Eterovic A Karina AK Yuan Yuan Y Li Jun J Nair Nikitha N Minelli Rosalba R Tsang Yiu Huen YH Cheung Lydia W T LWT Jeong Kang Jin KJ Roszik Jason J Ju Zhenlin Z Woodman Scott E SE Lu Yiling Y Scott Kenneth L KL Li Jin Billy JB Mills Gordon B GB Liang Han H
Cancer cell 20151001 4
Adenosine-to-inosine (A-to-I) RNA editing is a widespread post-transcriptional mechanism, but its genomic landscape and clinical relevance in cancer have not been investigated systematically. We characterized the global A-to-I RNA editing profiles of 6,236 patient samples of 17 cancer types from The Cancer Genome Atlas and revealed a striking diversity of altered RNA-editing patterns in tumors relative to normal tissues. We identified an appreciable number of clinically relevant editing events, ...[more]
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