Eicosanoid storm in infection and inflammation.
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ABSTRACT:
SUBMITTER: Dennis EA
PROVIDER: S-EPMC4606863 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Eicosanoid storm in infection and inflammation.
Dennis Edward A EA Norris Paul C PC
Nature reviews. Immunology 20150703 8
Controlled immune responses to infection and injury involve complex molecular signalling networks with coordinated and often opposing actions. Eicosanoids and related bioactive lipid mediators derived from polyunsaturated fatty acids constitute a major bioactive lipid network that is among the most complex and challenging pathways to map in a physiological context. Eicosanoid signalling, similar to cytokine signalling and inflammasome formation, has primarily been viewed as a pro-inflammatory co ...[more]
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